Fwiffo Pimpernel Smith this seems like an article you should read
It's written by a practising Roman Catholic who as a group have a propensity towards self flagellation.
With my extremely limited attention span....
What goes up must come down. Professional arcs aren't straight lines to heaven or hell. I never thought differently since reading Boethius' Consolation of Philosophy. People in any position especially top of corporate pyramids need to change every three years or it becomes stagnant. Plus the little ones don't get a chance to move up.
Life moves in phases, or as my father says moves like chapters in a book - social circles, beliefs, paradigms, values. Don't spend an extraordinary amount of effort trying against the laws of physics to keep something from one chapter to another. Luckily I didn't have to go to Timbuktu India to ask a homeless guy to tell me or burn down my family as the black gymnast said she almost did to learn the lesson.
50s is your natural end. Unfortunately for us, unlike our ancestors, the miracles of medical science and modern society means we're living another lifetime after 50.
I remember being at a dinner with a bunch of late 20s crowd. None of them had kids and I would say most were single or dating and there was maximum one married couple. When the subject of entering your 40s came up one of them said, "40s? Don't you just get cancer and die after 40?"